Expression profile of plasma microRNAs and target genes in patients with complicated pregnancy

Aim: comparative analysis of the expression profile plasma microRNAs and target genes in patients with complicated pregnancy. Materials Methods. A prospective observational study parallel groups was carried out. The included 73 women divided into three groups: main group – 42 preeclampsia (PE), comparison 12 pregnant fetal growth retardation (FGR), control 19 clinically healthy uncomplicated An examination performed, which clinical characteristics microRNA blood using real-time polymerase chain reaction. Results. MicroRNA hsa-miR-210-5p hsa-miR-1972 were not identified any sample. Analyzing PE showed significant changes levels hsa-miR-517a-3p (p = 0.025), hsa-miR-517c-3p 0.036), hsa-miR-574-5p 0.015), < 0.001) an increase miR-20a-5p 0.046) compared to group. No differences found miRNA FGR Assessing influence studied on regulatory signaling pathways allowed establish that hsa-miR-miR-146a-5p, -181a-5p, -210-3p, -517a-3p, -517c-3p, -574-3p, -574-5p, -1304-5p are potential regulators reaction cascades involved pathogenesis. Conclusion. revealed circulating level indicate presence specific transcriptomic alterations during course